Best Italian Restaurant in Fort Pierce

Q: Where are you located?

We are located in Fort Pierce, FL at 2455 W Midway Rd

Authentic Italian food, Great Food, Eat In, Take Out, Drive Thru, or Delivery

Holiday Gift Cards: Get $10 Added for Every $50

Give a taste of Santos this holiday season. For every $50 you purchase in gift cards, get $10 added to your gift card. Buy $50 and receive $60 total value, or buy $100 and receive $120 total value. After purchasing, call (772) 241-9181 to have your bonus added to the same gift card. The bonus is added by the restaurant, not automatically at checkout. No cash back. Valid for gift card purchases November 1–December 31, 2026.

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Santo’s 50 years

Santo began cooking in his family’s Villabate restaurant and brought those traditions to Fort Pierce.

Our story

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Wood-fired pizza

Our dough and sauce are made from scratch. The oven gives each pizza its thin, crispy crust.

Wood-fired pizza

Happy hour, Tuesday through Friday

Happy hour runs 4–7 pm with beer, wine, and appetizers.

Happy hour & specials

Catering on the Treasure Coast

We cater pickup and delivery for celebrations, weddings, corporate events, and gatherings.

From the oven

The grandmas Sicilian is the best I’ve ever had. I’m so tired of everyone saying they make the best pizza. Most of it’s garbage. This however is a game changer. Gonna go through this whole menu and update. This is the best pizza I’ve had in years though.

brooks B.

Hands down one of the best Chicken Parm sandwiches I’ve had in the area. Pro tip: sub the sauce for their vodka sauce, you won’t regret it! Great food and great people! Five stars

Alexander G.

I've ordered multiple times and everything was on point, love the steak and cheese subs the Grandma's and regular Sicilian pizza are delicious, Wings have to be the best I've had in town for a long time, they keep it up and I'll order from them exclusivley

Kristofer W.

The Pizza, and especially the Cheese Steak! One if not the best cheese steak in Florida

Kenneth S.

If you've been searching for great pizza around here, stop looking and go to Santos Wood Fired Pizza. It's surprisingly hard to find truly good pizza in this area, but this place absolutely delivers. The wood-fired crust is perfectly cooked with just the right amount of crispness and flavor, and you can tell they use quality ingredients. Everything tasted fresh, authentic, and made with care. It's easily some of the best pizza I've had locally.

Andrea M.

Santos Wood Fired Pizza Rewards

Join our rewards program, earn points every time you order online and redeem your points for free food!

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Frequently Asked Questions

What are you known for?

We are known for Buffalo Chicken Pizza, Meatballs, Arancini, Tiramisu, Carbonara, Bruschetta, Focaccia, Panna Cotta, Salads, Margherita Pizza, Deep Dish, Mozzarella Sticks, Cannoli, Seafood Pizza, Calzone, Calamari Fritti, Caprese, Calamari, Ravioli, Minestrone Soup, Cheesecake, Pasta, Chicken Parmesan, Spaghetti, Lasagna, Minestrone, Wings, Caesar Salad, Chicken Wings, Garlic Knots, Greek Salad, Pizza, Stromboli, Sicilian Pizza, Cheese Pizza, Hawaiian Pizza, and Caprese Salad

What meals do you serve?

We serve Lunch and Dinner

Do you offer delivery or takeout?

Yes, we offer Delivery and Takeout

Where are you located?

We are located in Fort Pierce, FL at 2455 W Midway Rd

What areas do you serve?

We serve the following areas: White City, Collins Park Estates, Fort Pierce South, Port St. Lucie, Fort Pierce, Indian River Estates, River Park, Glidden Park, Carlton, Ankona, Eldred, Sunland Gardens, St. Lucie County, Fort Pierce North, Paradise Park, Hutchinson Island South, Walton, St. Lucie Village, Eden, and Queens Cove.